Welcome to the Tao Lab!
Exploiting nanotechnology, synthetic biomaterials, and “living materials” in translational medicine for better human healthcare
《Nature Nanotechnology》: Nanotechnology-based strategies against SARS-CoV-2 variants
《Nature Nanotechnology》: Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment
《Nature Medicine》: The landscape of mRNA nanomedicine
《Nature Protocols》: Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages
《PNAS》: In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment
《Nature Reviews Cancer》: mRNA-based cancer therapeutics
《PNAS》: Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection
《Nature Reviews Cardiology》: Macrophage-targeted nanomedicine for diagnosis and treatment of atherosclerosis
《PNAS》: Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer
《Nature Reviews Materials》: A materials science perspective on tackling COVID-19
《Science Translational Medicine》: Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition
《Nature Communications》: Microalgae-based oral microcarriers for gut microbiota homeostasis and intestinal protection in cancer radiotherapy
《Nature Communications》: Capturing functional two-dimensional nanosheets from sandwich-structure vermiculite for cancer theranostics
《Nature Communications》: Nanosensitizer-mediated augmentation of sonodynamic therapy efficacy and antitumor immunity
《JACS》: Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota
Research Interest
Recent Publications
• Huang X, … , Tao W*. Oral delivery of liquid mRNA therapeutics by an engineered capsule for treatment of preclinical intestinal disease. Science Translational Medicine 2025.
• Chen S, … , Tao W*. Using RNA therapeutics to promote healthy aging. Nature Aging 2025, 5(6): 968-983.
• Liu C, … , Tao W*. Systemic reprogramming of tumour immunity via IL-10-mRNA nanoparticles. Nature Nanotechnology 2025.
• Zhou Z, … , Tao W*. Nanomedicine-based strategies for the treatment of vein graft disease. Nature Reviews Cardiology 2025, 22(4): 255-272.
• He Z, … , Tao W*. Resolvin D1 delivery to lesional macrophages using antioxidative black phosphorus nanosheets for atherosclerosis treatment. Nature Nanotechnology 2024, 19(9): 1386-1398.
• Tang Z, … , Tao W*. Inhaled mRNA nanoparticles dual-targeting cancer cells and macrophages in the lung for effective transfection. PNAS 2023, 120(44): e2304966120.
• Chen S, ... , Tao W*. Nanotechnology-based mRNA vaccines. Nature Reviews Methods Primers 2023, 3: 63.
• Liu C, ... , Tao W*. mRNA-based cancer therapeutics. Nature Reviews Cancer 2023, 23(8): 526-543.
• Ouyang J, … , Tao W*. Oral hydrogel microbeads-mediated in situ synthesis of selenoproteins for regulating intestinal immunity and microbiota. JACS 2023, 145(22): 12193–12205.
• Yu L, … , Tao W*. In Situ Separable Nanovaccines with Stealthy Bioadhesive Capability for Durable Cancer Immunotherapy. JACS 2023, 145(15): 8375-8388.
• Huang X, ... , Tao W*. The landscape of mRNA nanomedicine. Nature Medicine 2022, 28(11): 2273–2287.
• Huang X, ... , Tao W*. Nanotechnology-based strategies against SARS-CoV-2 variants. Nature Nanotechnology 2022, 17 (10): 1027–1037.
• Kong N, … , Tao W*. Intravesical delivery of KDM6A-mRNA via mucoadhesive nanoparticles inhibits the metastasis of bladder cancer. PNAS 2022, 119(7): e2112696119.
• Huang X, … , Tao W*. Synthesis of siRNA nanoparticles to silence plaque-destabilizing gene in atherosclerotic lesional macrophages. Nature Protocols 2022, 17(3):748–780.
• Chen W, … , Tao W*. Macrophage-targeted nanomedicine for diagnosis and treatment of atherosclerosis. Nature Reviews Cardiology 2022, 19(4): 228–249.
• Ouyang J, … , Tao W*. In situ sprayed NIR-responsive, analgesic black phosphorus-based gel for diabetic ulcer treatment. PNAS 2020, 117(46): 28667-28677.
• Tang Z, … , Tao W*. A materials science perspective on tackling COVID-19. Nature Reviews Materials 2020, 5(11): 847-860.
• Kong N, Tao W*, et al. Synthetic mRNA nanoparticle-mediated restoration of p53 tumor suppressor sensitizes p53-deficient cancers to mTOR inhibition. Science Translational Medicine 2019, 11(523): eaaw1565.
Sponsors: The Tao Lab is supported by
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Academic Life
Lab Activities and Entertainments
Interested in our lab? Let’s Work Together!
We’re always welcoming candidates, who are self-motivated and have a strong sense of responsibility, to join our team with different roles. Please feel free to reach out, and send the CV and names of three references to Dr. Tao (wtao@bwh.harvard.edu).